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| CAS:227472-48-2:Aminocandin | |
| Aminocandin is a new-generation echinocandin antifungal cyclic lipopeptide. It non-competitively inhibits fungal cell wall -1,3-glucan synthase, disrupts fungal cell wall structure, and exerts potent fungicidal activity against pathogenic fungi such as Candida and Aspergillus. Applied in invasive fungal infection mechanism research, antifungal drug development and fungal cell wall biology research. | |
| 90%/95%/98% | |
| ~1150 (subject to actual fermentation batch) |
| Function Tags (comma-separated) | ||||||||
| Aminocandin; Echinocandin antifungal peptide; CAS 227472-48-2 | Antifungal activity, -glucan synthesis inhibition,Echinocandin class,Invasive fungal infection,Candida/Aspergillus,Cyclic lipopeptide antibiotic | Large cyclic lipopeptide, no precise small-molecule formula; subject to actual batch MS | - | ~1150 (theoretical) |
| Long-term Storage Conditions | Short-term Storage Conditions | ||||
| PEP-AMC001 | White to off-white amorphous powder | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid high temperature, humidity and strong acid/base | Solid powder stable for 2 years at 2-8℃ sealed and dry; stock solutions prepared in DMSO | Stable for 72 h at 4℃ under anhydrous conditions. Prone to aggregation and degradation in aqueous phase; **poor aqueous solution stability**. **Limited water solubility, DMSO or aqueous organic solvent required for solubilization**. Ester and amide bonds easily hydrolyzed under acid/base. Aromatic side chains prone to photooxidation | Stable for 2 years at -20℃ under dry & dark conditions |
| Applicable Research Areas (comma-separated) | ||||
| PEP-AMC001 | New-generation echinocandin antifungal cyclic lipopeptide that inhibits -glucan synthase and potently kills pathogenic fungi | Aminocandin is a structurally optimized echinocandin antifungal agent. Amino modifications are introduced on the basis of the native cyclic hexalipopeptide backbone to improve water solubility and pharmacokinetic properties. It specifically binds to the -1,3-glucan synthase complex on the fungal cell membrane, non-competitively inhibits the catalytic activity of the enzyme, blocks the synthesis of -1,3-glucan, the core component of the fungal cell wall, leading to cell wall structural defects and osmotic imbalance, and ultimately triggers fungal cell lysis and death. This molecule exhibits potent fungicidal activity against clinically common pathogenic fungi such as Candida and Aspergillus, and maintains good activity against azole-resistant fungal strains. It serves as a core tool molecule for invasive fungal infection mechanism research, antifungal drug SAR optimization, and fungal cell wall synthesis pathway analysis. | Invasive fungal infection research,Antifungal drug development,Fungal cell wall biology,Candida/Aspergillus study,Echinocandin pathway study,Drug-resistant fungi research | Fungal -1,3-glucan synthase; Cell wall polysaccharide synthesis blockade pathway; Fungal osmotic lysis pathway |
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