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| CAS:1402-82-0:Amphomycin | |
| Amphomycin is a natural cyclic lipopeptide antibiotic. It specifically binds the bacterial cell wall precursor Lipid II, blocks the peptidoglycan polymerization process, inhibits Gram-positive bacterial cell wall synthesis, and exhibits potent antibacterial activity against clinical strains such as Staphylococcus aureus and Streptococcus. Applied in drug-resistant Gram-positive infection mechanism research, novel antibiotic development and cell wall synthesis pathway research. | |
| 90%/95%/98% | |
| C₅₉H₉₃N₁₃O₂₀ | |
| ~1272.45 (subject to actual fermentation batch) |
| Non-ribosomal acidic cyclic lipopeptide with unsaturated fatty acid side chain modification |
| Function Tags (comma-separated) | ||||||||
| Amphomycin; Cyclic lipopeptide antibiotic; CAS 1402-82-0 | Anti-Gram-positive bacteria,Cell wall synthesis inhibition,Lipid II targeting,Cyclic lipopeptide class,Natural antibiotic,Gram-positive bacteria study | Macrocyclic peptide backbone cyclized via head-to-tail amide bond, N-terminal conjugated with unsaturated long-chain fatty acid | 1271.66 | 1272.45 | Head-to-tail amide bond macrocyclization | Non-ribosomal acidic cyclic lipopeptide |
| Long-term Storage Conditions | Short-term Storage Conditions | ||||
| PEP-AMP001 | Store at -20℃, strictly protected from light, sealed and dry, aliquoted; avoid high temperature and acid/base | Solid powder stable for 2 years at 2-8℃ sealed and dry; stock solutions prepared in chloroform/methanol | Stable for 72 h at 4℃ under anhydrous & dark conditions. Prone to precipitation and inactivation in aqueous phase; **aqueous solution extremely unstable**. **Extremely poor water solubility, chloroform, methanol or DMSO required**. Unsaturated side chain prone to oxidative degradation. Peptide bond easily hydrolyzed under acid/base conditions | Stable for 2 years at -20℃ under dry & dark conditions |
| Applicable Research Areas (comma-separated) | ||||
| PEP-AMP001 | Natural acidic cyclic lipopeptide antibiotic that targets Lipid II to block cell wall synthesis and potently inhibit Gram-positive bacteria | Amphomycin is a non-ribosomal cyclic lipopeptide antibiotic produced by Streptomyces fermentation. The molecule forms a typical amphiphilic structure consisting of a hydrophilic macrocyclic peptide ring and a hydrophobic fatty acid side chain. It specifically binds the cell wall precursor Lipid II on the outer side of the bacterial cytoplasmic membrane, forms a stable complex and sterically blocks substrate binding of transglycosylase, inhibits peptidoglycan chain elongation and cell wall synthesis, and ultimately leads to bacterial osmotic lysis and death. This molecule exhibits potent antibacterial activity against various Gram-positive bacteria such as Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus pyogenes, and has no cross-resistance with -lactam antibiotics. It serves as a classic tool molecule for Gram-positive infection mechanism research, cell wall synthesis pathway analysis, and novel lipopeptide antibiotic SAR optimization. | Gram-positive bacteria research,Drug-resistant infection study,Bacterial cell wall biology,Lipid II target study,Natural antibiotic development,Microbial pharmacology research |
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